Abstract | BACKGROUND: Polymorphisms of Fc receptors for IgG (Fc gamma R) have been proposed as a genetic factor that influences susceptibility for systemic lupus erythematosus (SLE). Human Fc gamma RIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracellular domain ( histidine or arginine respectively) and differ substantially in their ability to bind human IgG2. The H131 allele binds IgG2 efficiently, whereas R131 binds it poorly. Because IgG2 is a poor activator of the classical complement pathway, the H131 is essential for the disposal of IgG2 immune complexes. AIM: PATIENTS AND METHODS: We studied 52 Chilean SLE patients fulfilling the 1982 American College of Rheumatology (ACR) criteria, 20 of whom had a history of nephritis, and 44 ethnically matched disease-free controls. Fc gamma RIIa allotypes were genotyped by PCR. RESULTS: No significant association was observed between the low affinity Fc gamma RII receptor (FcgRIIa-R131) and the presence of SLE or lupus nephritis. However, genotype frequencies in SLE patients but not in controls, departed from the proportions predicted by the Hardy-Weinberg equilibrium, suggesting this locus might be related to the disease. CONCLUSIONS: Our results suggest that in Chilean patients with SLE, as well as in many other populations, the R131 allotype is not a major factor predisposing to the development of SLE or lupus nephritis.
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Authors | Flavio Carrión, Fernando Figueroa, M Eugenia Martínez, Loreto Massardo, Tamara Pérez, Carolina Foster, Cecilia Mancilla, Oscar Neira, Leonardo Guzmán, Viviana Valenzuela, Ramón Urrutia, Sergio Carmona, Maximiliano Figueroa, Alessandra Lubiano, Eduardo Wainstein |
Journal | Revista medica de Chile
(Rev Med Chil)
Vol. 131
Issue 1
Pg. 11-8
(Jan 2003)
ISSN: 0034-9887 [Print] Chile |
Vernacular Title | Estudio del polimorfismo de receptores Fc gamma IIa en pacientes chilenos con lupus eritematoso sistémico. |
PMID | 12643213
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD
- Fc gamma receptor IIA
- Receptors, IgG
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Topics |
- Alleles
- Antigens, CD
(genetics)
- Chile
- Cohort Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lupus Erythematosus, Systemic
(genetics)
- Lupus Nephritis
(genetics)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, IgG
(genetics)
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