Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats.

Abstract

Di(2-ethylhexyl) adipate (DEHA) has replaced the phthalates in thin plasticized polyvinyl chloride films used for food packaging, mainly because some phthalates induce testis toxicity and antiandrogenic effects. A dose-range finding study followed by a dose-response/effect study in Wistar rats investigated whether pre- and postnatal DEHA doses of 0, 800, or 1200mg/kg/day body weight and doses of 0, 200, 400, or 800mg/kg/day (main study) elicited developmental toxicity including antiandrogenic effects. In the main study, DEHA induced a prolonged gestation period (800mg/kg/day) and a dose-related increase in postnatal death (400 and 800mg/kg/day). DEHA also induced a permanent decrease in offspring body weight (800mg/kg/day). No antiandrogenic endpoints were affected. We conclude that DEHA induced developmental toxicity and the NOAEL is 200mg/kg. DEHA did not induce antiandrogenic effects similar to those of di(2-ethylhexyl) phthalate even though the chemical structures have similarities and the two chemicals have a common metabolite.

• Authors: Majken Dalgaard, Ulla Hass, Anne Marie Vinggaard, Kirsten Jarfelt, Henrik R Lam, Ilona K Sørensen, Helle M Sommer, Ole Ladefoged
• Journal: Reproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol) 2003 Mar-Apr Vol. 17 Issue 2 Pg. 163-70 ISSN: 0890-6238 [Print] United States
• PMID: 12642148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androgen Antagonists
• Androgens
• Teratogens
• Testosterone
• Diethylhexyl Phthalate

Topics

• Androgen Antagonists (toxicity)
• Androgens (biosynthesis)
• Animals
• Birth Weight (drug effects)
• Diethylhexyl Phthalate (toxicity)
• Dose-Response Relationship, Drug
• Female
• Fetal Death (chemically induced)
• Genitalia, Male (drug effects, growth & development)
• Growth (drug effects)
• Litter Size (drug effects)
• Male
• Organ Size (drug effects)
• Pregnancy
• Prenatal Exposure Delayed Effects
• Rats
• Rats, Wistar
• Sperm Count
• Sperm Motility (drug effects)
• Spermatozoa (drug effects)
• Teratogens
• Testosterone (biosynthesis)
• Weight Gain (drug effects)