Aggressive systemic mastocytosis.

Abstract

Systemic mastocytosis is a rare and occasionally aggressive condition that raises major diagnostic challenges. We report a case in a 72-year-old patient in whom the diagnosis of malignant mastocytosis required two bone marrow smears and three bone marrow biopsies examined using specific staining techniques. Despite interferon therapy, a mast-cell sarcoma of the sternum developed 1 year after symptom onset, followed 1 year later by acute myeloblastic leukemia, which was rapidly fatal.

• Authors: Rachida Inaoui, Barbara Petit, Arnaud Jaccard, Philippe Bertin, Richard Trèves
• Journal: Joint bone spine (Joint Bone Spine) Vol. 70 Issue 1 Pg. 64-6 (Feb 2003) ISSN: 1297-319X [Print] France
• PMID: 12639621 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interferon-alpha
• Serine Endopeptidases
• Tryptases
• Prednisone
• Alendronate

Topics

• Aged
• Alendronate (therapeutic use)
• Bone Marrow Cells (enzymology, pathology)
• Fatal Outcome
• Female
• Humans
• Interferon-alpha (therapeutic use)
• Leukemia, Myeloid, Acute (pathology)
• Mast Cells (enzymology, pathology)
• Mast-Cell Sarcoma (pathology)
• Mastocytosis, Systemic (complications, pathology, therapy)
• Neoplasms, Multiple Primary
• Osteoporosis, Postmenopausal (drug therapy)
• Prednisone (therapeutic use)
• Serine Endopeptidases (metabolism)
• Tryptases