Abstract | OBJECTIVE: DATA SOURCES: A MEDLINE search, restricted to English language, was conducted from 1990 to June 2002. Supplementary sources included program abstracts from the Interscience Conference on Antimicrobial Agents and Chemotherapy and the Infectious Diseases Society of America from 1996 to 2001 and manufacturer information available through the Food and Drug Administration's Web site. DATA EXTRACTION: All published and unpublished trials and abstracts citing voriconazole were selected. DATA SYNTHESIS:
Voriconazole has shown in vitro activity against many yeasts and a variety of mold and dermatophyte isolates. Voriconazole can be administered either orally or parenterally. It exhibits good oral bioavailability, wide tissue distribution including distribution into the central nervous system, and hepatic metabolism. Drug interactions occur through inhibition of the CYP2C9, CYP2C19, and CYP3A4 isoenzymes, resulting in alterations in kinetic parameters of either voriconazole or the interacting agent. Efficacy has been illustrated in open, noncomparative studies of aspergillosis in immunocompromised patients. Human case reports describe successful treatment of rare fungal pathogens. The most commonly reported adverse events include visual disturbances and elevations in liver function tests. CONCLUSIONS:
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Authors | Margaret M Pearson, P David Rogers, John D Cleary, Stanley W Chapman |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 37
Issue 3
Pg. 420-32
(Mar 2003)
ISSN: 1060-0280 [Print] United States |
PMID | 12639175
(Publication Type: Journal Article, Review)
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Chemical References |
- Antifungal Agents
- Pyrimidines
- Triazoles
- Voriconazole
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Topics |
- Antifungal Agents
(pharmacokinetics, pharmacology, therapeutic use)
- Drug Administration Schedule
- Drug Interactions
- Formularies as Topic
- Humans
- Length of Stay
(economics)
- Mycoses
(drug therapy, prevention & control)
- Pyrimidines
(pharmacokinetics, pharmacology, therapeutic use)
- Randomized Controlled Trials as Topic
- Triazoles
(pharmacokinetics, pharmacology, therapeutic use)
- Voriconazole
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