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Cell proliferation and natural killer cell activity by polyherbal formulation, Immu-21 in mice.

Abstract
Immunomodulatory activity of an Ayurvedic polyherbal formulation, Immu-21 containing extracts of Ocimum sanctum, Withania somnifera, Emblica officinalis and Tinospora cordifolia was studied on proliferative response of splenic leukocytes to T cell mitogens, concanavalin (Con)-A and phytohemagglutinin (PHA) and B cell mitogen, lipopolysaccharide (LPS) in vitro by [3H]-thymidine uptake assay in mice. The cytotoxic activity of Immu-21 was tested by measuring the splenic leukocyte natural killer (NK) cell activity against K 562 cells. Intraperitoneal (i.p.) treatment with Immu-21 (30 mg/kg) once a day for 14 and 21 days did not cause change in body weight and spleen weight, where as splenocytes/spleen count was increased. Treatment of Immu-21 (30 mg/kg, i.p.) for 14 days and 1 mg/kg for 21 days significantly increased LPS induced leukocyte proliferation. NK cell activity was significantly increased when mice were pretreated with Immu-21 (10 and 30 mg/kg, i.p.) once a day for 7 days. The results indicate that pretreatment with Immu-21 selectively increased the proliferation of splenic leukocyte to B cell mitogen, LPS and cytotoxic activity against K 562 cells in mice.
AuthorsKumar V S Nemmani, G B Jena, C S Dey, C L Kaul, P Ramarao
JournalIndian journal of experimental biology (Indian J Exp Biol) Vol. 40 Issue 3 Pg. 282-7 (Mar 2002) ISSN: 0019-5189 [Print] India
PMID12635697 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Plant Extracts
Topics
  • Adjuvants, Immunologic (pharmacology)
  • B-Lymphocytes (drug effects, immunology)
  • Cytotoxicity, Immunologic (drug effects)
  • Humans
  • K562 Cells
  • Killer Cells, Natural (drug effects, immunology)
  • Lymphocyte Activation (drug effects)
  • Medicine, Ayurvedic
  • Plant Extracts (pharmacology)
  • Plants, Medicinal
  • T-Lymphocytes (drug effects, immunology)

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