[In-vitro comparison of the effectiveness of different high-speed rotatory catheters].

Abstract

OBJECTIVE:

To determine the in vitro effectiveness of the Amplatz and Rotarex catheters for thrombus fragmentation and combined thrombus fragmentation and aspiration.

MATERIALS AND METHODS:

Clots (n = 100) from 5-day-old porcine blood (8.5 g) were fragmented with the 8F Rotarex trade mark catheter (RR; 40.000 rpm), which was directed with or without a coaxial guide wire (GW 0.020 inch [8 F RR(GW)], GW 0.014 inch [6 F RR(GW)]), and with the 7 F Amplatz catheter (ATD; 150.000 rpm), in an artery flow model (pulsed flow of 700 ml/min) simulating the superficial femoral artery. To increase the wall adherence of the thrombus, an additional equal number of silicon tubes (with an inner diameter of 7 mm) were fitted inside with a metallic mesh (wall-adherent thrombus [WAT]; 6 F RR(WAT), 8 F RR(WAT), 6 F R(WAT-GW), 8 F RR(WAT-GW), ATD(WAT) ). The effluent was passed through a three-step filter system (10 to 1000 micro m; pressure gradient 35 mmHg).

RESULTS:

Highest effectiveness was found for 8 F RR (no remaining thrombus detectable) compared to 6 F RR (0.08 g) and ATD (0.07 g), with a p < 0.001 for both methods. The aspirated volume was significantly lower when 6 F and 8 F RR were used with a coaxial guide wire (p < 0.001). The total emboli rate for 8 F RR was significantly lower compared to ATD (p < 0.001). Even when working without a guide wire, 8 F RR caused the lowest proportion of emboli (depending on the modification 0.12 % to 1.76 %; compared to all p < 0.05). Emboli rates reached 7.99 % for 6 F RR (compared to all p < 0.001) and were maximal 5.61 % for ATD.

CONCLUSIONS:

The tested mechanical thrombectomy catheters have a high potential for in vitro thrombectomy with moderate performance differences. In contrast to the guidewire-directed Rotarex fragmentation-aspiration device, the ATD trade mark fragmentation catheter and prototype Rotarex 6 F catheter have a considerable peripheral embolization rate of particles larger than 1000 micro m, probably requiring additional measures for in vivo thrombectomy.

• Authors: S Müller-Hülsbeck, D N Dimitte, T Jahnke, J Hedderich, J Grimm, M Heller
• Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (Rofo) Vol. 175 Issue 3 Pg. 406-12 (Mar 2003) ISSN: 1438-9029 [Print] Germany
• Vernacular Title: Vergleichende In-vitro-Untersuchungen zur Effektivität unterschiedlicher Hochgeschwindigkeits-Rotationskatheter.
• PMID: 12635019 (Publication Type: Comparative Study, English Abstract, Journal Article)

Topics

• Animals
• Catheterization
• Disease Models, Animal
• Embolism (complications, diagnosis)
• Recurrence
• Regression Analysis
• Swine
• Thrombectomy (instrumentation, methods)
• Thrombosis (surgery)
• Time Factors