Abstract | OBJECTIVE: STUDY DESIGN: Ten placentas that were obtained immediately after delivery were perfused with clarithromycin (3 microg/mL) plus a reference substance ( antipyrine). Open circulation placental preparations were used to evaluate steady-state pharmacodynamics and transplacental gradient formation. Drug concentrations were measured by high-performance liquid chromatography. RESULTS: The mean transplacental transfer of clarithromycin was 6.1% (95% CI, 1.8%). CONCLUSION: Because of its enhanced placental passage compared with other macrolide antibiotics, clarithromycin that is given after the first trimester (after embryogenesis) may be an appropriate candidate in treatment trials of genital mycoplasma and ureaplasma infections during pregnancy.
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Authors | Armin Witt, Eva Maria Sommer, Margit Cichna, Karl Postlbauer, Alexander Widhalm, Hubertus Gregor, Klaus Reisenberger |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 188
Issue 3
Pg. 816-9
(Mar 2003)
ISSN: 0002-9378 [Print] United States |
PMID | 12634663
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Clarithromycin
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Topics |
- Anti-Bacterial Agents
(pharmacokinetics)
- Chromatography, High Pressure Liquid
- Clarithromycin
(pharmacokinetics)
- Female
- Homeostasis
- Humans
- Placenta
(metabolism)
- Pregnancy
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