[Clinical experience with amoxicillin in otorhinolaryngology (author's transl)].

Abstract

This paper reports the clinical trial of amoxicillin. (1) A daily dose of 750 approximately 1,000 mg of amoxicillin was orally administered for 3 approximately 12 days to 20 patients, 7 of which were with acute suppurative tympanitis, 3 with furuncle of the ear, 2 with furuncle of the nose and 8 with acute amygdalitis. As a result, amoxicillin proved remarkably effective or effective in 17 patients (85.0%). (2) Amoxicillin was effective against: Staphylococcus aureus in 10 of 11 patients (90.9%) Staphylococcus epidermidis in 2 of 2 patients (100%) Streptococcus hemolyticus in 3 of 4 patients (75%) Streptococcus viridans in 1 of 1 patient (100%) Diplococcus pneumoniae in 1 of 1 patient (100%) (3) Although one patient developed drug eruption, there were no side effects that necessitated cessation of administration. From the above results, it is concluded that amoxicillin can be used in the treatment of otorhinolaryngologic infections.

• Authors: F Azuma
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 29 Issue 2 Pg. 197-200 (Feb 1976) ISSN: 0368-2781 [Print] Japan
• PMID: 1263345 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ampicillin
• Amoxicillin

Topics

• Adolescent
• Adult
• Amoxicillin (adverse effects, therapeutic use)
• Ampicillin (analogs & derivatives)
• Drug Evaluation
• Ear Diseases (drug therapy)
• Female
• Furunculosis (drug therapy)
• Humans
• Male
• Middle Aged
• Nose Diseases (drug therapy)
• Otitis Media (drug therapy)
• Otorhinolaryngologic Diseases (drug therapy)
• Staphylococcus (drug effects)
• Tonsillitis (drug therapy)