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Total synthesis of (+/-)-trachyspic acid and determination of the relative configuration.

Abstract
[reaction: see text] The first total synthesis of (+/-)-trachyspic acid, a tumor cell heparanase inhibitor, was accomplished based on Cr(II)/Ni(II)-mediated reaction of the aldehyde containing the citric acid moiety and the long-chain triflate, and the relative configuration of this natural product was determined.
AuthorsKanako Hirai, Hidenori Ooi, Tomoyuki Esumi, Yoshiharu Iwabuchi, Susumi Hatakeyama
JournalOrganic letters (Org Lett) Vol. 5 Issue 6 Pg. 857-9 (Mar 20 2003) ISSN: 1523-7060 [Print] United States
PMID12633090 (Publication Type: Journal Article)

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