Abstract | BACKGROUND: METHODS: RESULTS: DHG induced no major bleeding or clot formation during 3-hour hemodialysis, in contrast to UFH and LMWH, each of which induced marked bleeding. These glycosaminoglycans (GAGs) were equally effective in decreasing plasma levels of BUN and creatinine. On the other hand, dogs treated with FUT failed to complete 3-hour hemodialysis. These anticoagulants prolonged activated partial thromboplastin time (APTT) to different extents and GAGs prolonged thrombin clotting time markedly but FUT did not. CONCLUSION:
|
Authors | Kazuhisa Minamiguchi, Keiko T Kitazato, Hideki Nagase, Eiji Sasaki, Katsuo Ohwada, Kenji Kitazato |
Journal | Kidney international
(Kidney Int)
Vol. 63
Issue 4
Pg. 1548-55
(Apr 2003)
ISSN: 0085-2538 [Print] United States |
PMID | 12631372
(Publication Type: Journal Article)
|
Chemical References |
- Anticoagulants
- Fatty Acids, Nonesterified
- Glycosaminoglycans
- depolymerized holothurian glucosaminoglycan
|
Topics |
- Animals
- Anticoagulants
(pharmacology)
- Blood Cell Count
- Blood Coagulation
(drug effects)
- Disease Models, Animal
- Dogs
- Fatty Acids, Nonesterified
(blood)
- Glycosaminoglycans
(blood, pharmacology)
- Male
- Partial Thromboplastin Time
- Renal Dialysis
(methods)
- Renal Insufficiency
(therapy)
- Thrombin Time
|