Corticotropin-releasing factor receptor type 1 is involved in the stress-induced exacerbation of chronic contact dermatitis in rats.

Abstract

Cutaneous diseases such as psoriasis and atopic dermatitis are worsened by psychic stress. We attempted to clarify the involvement of the corticotropin-releasing factor (CRF) receptor (CRFR) in stress-induced exacerbation of chronic contact dermatitis in rats. Male Wistar rats, in which chronic contact dermatitis had been induced by 2,4,6-trinitro-1-chlorobenzene (TNCB), were exposed to a 1-h period of electric foot-shock following intraperitoneal administration of CRA1000, a selective CRFR type 1 (CRFR1) antagonist, or vehicle everyday for 9 days. Histological examination of the skin showed that the epidermis significantly thickened and the number of mast cells in the dermis significantly increased by repeated exposure to stress, and that these changes were blocked by CRA1000. These results suggest that CRFR1 is involved in the stress-induced exacerbation of chronic contact dermatitis.

• Authors: Katsumi Kaneko, Seiji Kawana, Keiko Arai, Tamotsu Shibasaki
• Journal: Experimental dermatology (Exp Dermatol) Vol. 12 Issue 1 Pg. 47-52 (Feb 2003) ISSN: 0906-6705 [Print] Denmark
• PMID: 12631246 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pyridines
• Pyrimidines
• Receptors, Corticotropin-Releasing Hormone
• Immunoglobulin E
• CRA1000
• CRF receptor type 1
• Picryl Chloride

Topics

• Animals
• Chronic Disease
• Dermatitis, Contact (blood, complications, etiology, pathology)
• Dermis (pathology)
• Electroshock
• Epidermis (drug effects, pathology)
• Foot
• Immunoglobulin E (blood)
• Male
• Mast Cells (pathology)
• Picryl Chloride
• Pyridines (pharmacology)
• Pyrimidines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Corticotropin-Releasing Hormone (antagonists & inhibitors, metabolism)
• Stress, Physiological (complications, etiology)