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Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia.

AbstractBACKGROUND:
The purpose of this prospective study was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy.
METHODS:
Patients were randomly assigned to one of three groups. Induction of anesthesia was performed with thiopentone 5 mg kg(-1) in Group I (n = 30), propofol 2 mg kg(-1) in Group II (n = 30), and propofol 3.5 mg kg(-1) in Group III (n = 30). Then succinylcholine 1 mg kg(-1) was administered to the patients for intubation.
RESULTS:
Fasciculation was absent in 20% of Group III patients, and no vigorous fasciculation occurred in this group. Furthermore, the severity of fasciculation in Group III was significantly lower than in the other two groups (P = 0.01). Seventy per cent of patients had no myalgia in Group III, 39.2% in Group II and 37% in Group I (P = 0.007). Severity of myalgia was also significantly lower in Group III compared with the other two groups (P = 0.011). Post-operative creatine kinase levels were significantly higher than their baseline values in Groups I and II (P < 0.0001).
CONCLUSION:
Administration of propofol 3.5 mg kg-1 is effective in reducing fasciculations and myalgia after succinylcholine.
AuthorsA Kararmaz, S Kaya, S Turhanoglu, M A Ozyilmaz
JournalActa anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 47 Issue 2 Pg. 180-4 (Feb 2003) ISSN: 0001-5172 [Print] England
PMID12631047 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
CopyrightCopyright Acta Anaesthesiologica Scandinavica 47 (2003)
Chemical References
  • Anesthetics, Intravenous
  • Neuromuscular Depolarizing Agents
  • Creatine Kinase
  • Succinylcholine
  • Propofol
Topics
  • Adult
  • Anesthetics, Intravenous (administration & dosage, therapeutic use)
  • Creatine Kinase (blood)
  • Double-Blind Method
  • Fasciculation (chemically induced, drug therapy)
  • Female
  • Gynecologic Surgical Procedures
  • Humans
  • Laparoscopy
  • Male
  • Neuromuscular Depolarizing Agents (adverse effects)
  • Neuromuscular Diseases (chemically induced, drug therapy)
  • Pain (chemically induced, drug therapy)
  • Pain, Postoperative (chemically induced, drug therapy)
  • Propofol (administration & dosage, therapeutic use)
  • Succinylcholine (adverse effects)

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