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Natural and synthetic sialic acid-containing inhibitors of influenza virus receptor binding.

Abstract
Influenza viruses attach to susceptible cells via multivalent interactions of their haemagglutinins with sialyloligosaccharide moieties of cellular glycoconjugates. Soluble macromolecules containing sialic acid from animal sera and mucosal fluids can act as decoy receptors and competitively inhibit virus-mediated haemagglutination and infection. Although a role for these natural inhibitors in the innate anti-influenza immunity is still not clear, studies are in progress on the design of synthetic sialic acid-containing inhibitors of receptor binding which could be used as anti-influenza drugs.
AuthorsMikhail Matrosovich, Hans-Dieter Klenk
JournalReviews in medical virology (Rev Med Virol) 2003 Mar-Apr Vol. 13 Issue 2 Pg. 85-97 ISSN: 1052-9276 [Print] England
PMID12627392 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright 2003 John Wiley & Sons, Ltd.
Chemical References
  • Antiviral Agents
  • Receptors, Virus
  • Sialic Acids
Topics
  • Animals
  • Antiviral Agents (chemical synthesis, chemistry, pharmacology)
  • Binding Sites (drug effects)
  • Humans
  • Orthomyxoviridae (drug effects, metabolism)
  • Receptors, Virus (antagonists & inhibitors, metabolism)
  • Sialic Acids (metabolism)

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