Review article: The pharmacological properties and clinical use of valdecoxib, a new cyclo-oxygenase-2-selective inhibitor.

Abstract	Cyclo-oxygenase-2-selective inhibitors produce less gastric damage than conventional non-steroidal anti-inflammatory drugs. Valdecoxib is a new orally administered cyclo-oxygenase-2-selective inhibitor, recently approved for use in osteoarthritis, rheumatoid arthritis and primary dysmenorrhoea in the USA. The drug has been evaluated in more than 60 clinical studies involving more than 14 000 patients and healthy volunteers. The analgesic efficacy of valdecoxib at a dose of 10 mg once daily in both osteoarthritis and rheumatoid arthritis is superior to that of placebo and similar to that of traditional non-steroidal anti-inflammatory drugs. Valdecoxib is effective in single doses of up to 40 mg for the alleviation of acute menstrual pain and has a rapid onset of action (within 30 min) and a long duration of analgesia (up to 24 h). Valdecoxib is well tolerated and has safety advantages compared with traditional non-steroidal anti-inflammatory drugs in terms of less gastrointestinal toxicity and a lack of an effect on platelet function. The incidence of adverse effects involving the kidney (fluid retention, oedema and hypertension) is similar to that of non-selective, non-steroidal anti-inflammatory drugs.
Authors	S Alsalameh, M Burian, G Mahr, B G Woodcock, G Geisslinger
Journal	Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 17 Issue 4 Pg. 489-501 (Feb 15 2003) ISSN: 0269-2813 [Print] England
PMID	12622757 (Publication Type: Journal Article, Review)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Isoenzymes Isoxazoles Membrane Proteins Sulfonamides valdecoxib Cyclooxygenase 2 PTGS2 protein, human Prostaglandin-Endoperoxide Synthases
Topics	Adult Aged Animals Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use) Arthritis, Rheumatoid (drug therapy) Biological Availability Bone Diseases (surgery) Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors (pharmacology, therapeutic use) Drug Interactions Dysmenorrhea (drug therapy) Female Humans Isoenzymes (antagonists & inhibitors) Isoxazoles (pharmacology, therapeutic use) Liver Diseases (complications) Male Membrane Proteins Middle Aged Mouth Diseases (surgery) Osteoarthritis (drug therapy) Pain (drug therapy) Prostaglandin-Endoperoxide Synthases Rats Sulfonamides (pharmacology, therapeutic use)

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