Effect of vitamin C on endothelial dysfunction during N-alpha-tosyl L-arginine methyl ester [TAME]-esterase induced contractions in rat aorta in vitro.

Abstract

Contractions induced by TAME-esterase on rat aorta strips mounted in vitro were significantly inhibited in presence of Vitamin C. The work lends support to the role of ascorbic acid in preventing endothelial dysfunction through release of nitric oxide. It is suggested that conclusions TAME-esterase could be an important biological marker associated with onset of vascular discases such as hypertension.

• Authors: F B H Gurib, A H Subratty
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 40 Issue 5 Pg. 617-9 (May 2002) ISSN: 0019-5189 [Print] India
• PMID: 12622214 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide Hydrolases
• tosylarginine methyl ester hydrolase
• Ascorbic Acid

Topics

• Animals
• Aorta, Thoracic (drug effects, physiology)
• Ascorbic Acid (pharmacology)
• Endothelium, Vascular (drug effects, physiology)
• In Vitro Techniques
• Muscle Contraction (drug effects)
• Peptide Hydrolases (pharmacology)
• Rats
• Rats, Sprague-Dawley