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Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease.

AbstractOBJECTIVE:
To investigate whether endolymphatic hydrops in Ménière's Disease could be diagnosed by comparing vestibular evoked myogenic potential (VEMP) before and after furosemide administration (F-VEMP).
STUDY DESIGN:
Retrospective study.
SETTING:
University hospital.
INTERVENTION:
Furosemide administration.
PATIENTS:
Twenty-five affected ears of patients with unilateral Ménière's Disease were studied. The patients had received confirmed diagnoses Ménière's Disease; thus, the presence of endolymphatic hydrops was suggested. For the control, 22 ears of 11 normal healthy volunteers who had never had vertigo or hearing disturbance were used.
MAIN OUTCOME MEASURE:
The amplitude of the p13-n23 biphasic wave before and after furosemide administration.
RESULTS:
The amplitude of the p13-n23 biphasic wave was significantly enlarged in 7 of 18 cases in which it could be detected before diuretic loading. The biphasic waves appeared after diuretic loading in 3 of 7 cases in which it could not be recorded before loading. Thus, the positive ratio of F-VEMP for unilateral Ménière's Disease was considered to be 40% (10 of 25). The ratio was similar to that of the conventional examinations for endolymphatic hydrops such as the glycerol test, furosemide test, and electrocochleogram.
CONCLUSION:
The F-VEMP test may be useful in the diagnosis of endolymphatic hydrops.
AuthorsToru Seo, Michiko Node, Akiko Yukimasa, Masafumi Sakagami
JournalOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (Otol Neurotol) Vol. 24 Issue 2 Pg. 283-8 (Mar 2003) ISSN: 1531-7129 [Print] United States
PMID12621345 (Publication Type: Journal Article)
Chemical References
  • Diuretics
  • Furosemide
  • Glycerol
Topics
  • Adult
  • Aged
  • Audiometry, Evoked Response
  • Diuretics (administration & dosage, therapeutic use)
  • Endolymphatic Hydrops (diagnosis, physiopathology)
  • Evoked Potentials (physiology)
  • Female
  • Furosemide (administration & dosage)
  • Glycerol
  • Humans
  • Injections, Intravenous
  • Male
  • Meniere Disease (diagnosis, physiopathology)
  • Middle Aged
  • Muscle, Skeletal (physiopathology)
  • Severity of Illness Index
  • Supine Position
  • Time Factors
  • Vestibule, Labyrinth (physiopathology)

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