Abstract | BACKGROUND AND OBJECTIVES: METHODS: RESULTS: The enzyme level in the carcinomas was 4-fold that of adjacent uninvolved breast tissues (101 vs 23 pmol/min/mg protein, P < 0.001). Enzyme activity in intraductal papilloma (120 pmol/min/mg protein) was comparable to that in invasive carcinoma. There were no significant differences in DPD activity related to clinicopathologic features, but a tendency toward increased DPD activity was observed in progesterone receptor-negative breast cancer (P = 0.09). There was marginal correlation in enzyme activity between primary and metastatic lesions (P = 0.07). CONCLUSIONS: DPD activity is substantially upregulated in breast cancer tissue and is higher than that reported previously. The clinical implications of DPD inhibitors in patients being treated for breast cancer with oral fluoropyrimidine chemotherapy should be further investigated.
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Authors | Keisei Anan, Shoshu Mitsuyama, Keiyoshi Tamae, Nobuhiro Suehara, Kazuyoshi Nishihara, Yoshiaki Ogawa, Yuji Abe, Toshimitsu Iwashita, Satoshi Toyoshima |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 82
Issue 3
Pg. 174-9
(Mar 2003)
ISSN: 0022-4790 [Print] United States |
PMID | 12619061
(Publication Type: Journal Article)
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Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Antimetabolites, Antineoplastic
- Oxidoreductases
- Dihydrouracil Dehydrogenase (NADP)
- Fluorouracil
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Topics |
- Adult
- Aged
- Antimetabolites, Antineoplastic
(pharmacology)
- Breast Neoplasms
(drug therapy, enzymology)
- Carcinoma, Ductal, Breast
(drug therapy, enzymology)
- Carcinoma, Intraductal, Noninfiltrating
(drug therapy, enzymology)
- Catalysis
- Dihydrouracil Dehydrogenase (NADP)
- Female
- Fluorouracil
(pharmacology)
- Humans
- Middle Aged
- Oxidoreductases
(pharmacology)
- Prospective Studies
- Up-Regulation
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