Prevention of secretagogue-induced ulcers in the rat.

Abstract	An inhibitor of gastric secretion, Pfizer UK -9040, a derivative of the antihistamine triprolidine, was given orally 50 to 100 mg per kg 1 hr before and at various times during a 24-hr subcutanwous infusion of ulcerogenic secretagogues. The higher the dose and the more frequent the dosage, the lower was the incidence, severity, number, and perforations of duodenal ulcers. The mechanisms by which UK -9040 prevents these ulcers is probably inhibition of gastric secretion.
Authors	S N Joffe, R J Gaskin, A A D'Sa
Journal	Gastroenterology (Gastroenterology) Vol. 70 Issue 5 PT.1 Pg. 751-2 (May 1976) ISSN: 0016-5085 [Print] United States
PMID	1261768 (Publication Type: Journal Article)
Chemical References	Pyridines Triprolidine Histamine Carbachol Pentagastrin
Topics	Animals Carbachol Dose-Response Relationship, Drug Duodenal Ulcer (chemically induced, prevention & control) Gastric Juice (metabolism) Histamine Male Pentagastrin Peptic Ulcer Perforation (prevention & control) Pyridines (therapeutic use) Rats Stimulation, Chemical Triprolidine (analogs & derivatives, therapeutic use)

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