Microencapsulation and modification of synthetic peptides of food proteins reduces the blood pressure of spontaneously hypertensive rats.

Abstract

Synthetic peptides were microencapsulated into liposomes, cycled with a disulfide bond or modified with d-phenylglycine (d-phg) at the N-terminal, and their antihypertensive effects as orally administered (0.18 mM/kg body weight) to spontaneously hypertensive rats (SHR) were measured. The microencapsulated Leu-Lys-Pro reduced significantly the systolic blood pressures of SHR by 45 mmHg and showed a prolonged duration, revealing the significant protective effect of encapsulation. d-phg-Leu-Arg-Pro showed a duration about 2 h shorter than that of the peptide without modification. In addition, cyclic Leu-Arg-Pro peptide with a disulfide bond between the N- and C-terminal amino acids reduced the systolic blood pressure of SHR by 35 mmHg and displayed a lengthy duration.

• Authors: Tzy-Li Chen, Yung-Chieh Lo, Wei-Tze Hu, Ming-Chang Wu, Shui-Ten Chen, Hung-Min Chang
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 51 Issue 6 Pg. 1671-5 (Mar 12 2003) ISSN: 0021-8561 [Print] United States
• PMID: 12617603 (Publication Type: Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Antihypertensive Agents
• Dietary Proteins
• Liposomes
• Peptides
• Peptides, Cyclic
• Captopril

Topics

• Amino Acid Sequence
• Angiotensin-Converting Enzyme Inhibitors (administration & dosage)
• Animals
• Antihypertensive Agents (administration & dosage)
• Blood Pressure (drug effects)
• Captopril (pharmacology)
• Dietary Proteins (analysis)
• Hydrolysis
• Kinetics
• Liposomes (chemistry)
• Peptides (administration & dosage, chemistry)
• Peptides, Cyclic (administration & dosage, chemistry)
• Rats
• Rats, Inbred SHR
• Structure-Activity Relationship