Relationship between serum N-carbamoyl-beta-D-glucopyranosylamine level and renal failure.

Abstract

A statistical investigation was carried out on the distribution of serum N-carbamoyl-beta-D-glucopyranosylamine (NCG) among various patient groups. The serum NCG levels of patients treated in the departments of hemodialysis (131 +/- microM), nephritic syndrome (47 +/- 54 microM), and diabetes mellitus (55 +/- 70 microM) were significantly higher (p < 0.01) than those in other internal disease patients (18 +/- 22 microM) and healthy volunteers (6 +/- 22 microM). The serum NCG level was greatly reduced by hemodialysis therapy, however a return to initial NCG levels was observed within about one week. These results indicate that a high serum NCG level is a feature of renal failure patients, and a relationship was demonstrated between hyperuremia and NCG formation and accumulation in blood.

• Authors: Tetsuro Hamafuji, Wakako Tsugawa, Koji Sode
• Journal: Renal failure (Ren Fail) Vol. 25 Issue 1 Pg. 115-21 (Jan 2003) ISSN: 0886-022X [Print] England
• PMID: 12617339 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Biomarkers
• antibiotic SF 1933
• Glucosamine

Topics

• Biomarkers (blood)
• Diabetes Mellitus (blood)
• Glucosamine (analogs & derivatives, blood)
• Humans
• Renal Dialysis
• Renal Insufficiency (blood, therapy)
• Syndrome