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Immune responses in hepatitis B virus infection.

Abstract
Hepatitis B virus infection is one of the most frequent causes of chronic liver disease worldwide. Even though a preventive vaccine is available, the search for a cure for chronically infected patients remains a high priority to reduce the morbidity and mortality from liver cirrhosis and hepatocellular carcinoma. This review summarizes the immune response in acute, self-limited and chronic hepatitis B; its differential effects on viral replication and liver injury; and prospects for immunotherapy.
AuthorsBarbara Rehermann
JournalSeminars in liver disease (Semin Liver Dis) Vol. 23 Issue 1 Pg. 21-38 (Feb 2003) ISSN: 0272-8087 [Print] United States
PMID12616448 (Publication Type: Journal Article, Review)
Chemical References
  • Antiviral Agents
  • Hepatitis B Vaccines
Topics
  • Antibody Formation
  • Antiviral Agents (immunology, pharmacology)
  • Carcinoma, Hepatocellular (etiology, virology)
  • Hepatitis B Vaccines (therapeutic use)
  • Hepatitis B, Chronic (complications, immunology, pathology)
  • Humans
  • Immunity, Cellular
  • Immunotherapy
  • Liver Cirrhosis (etiology, virology)
  • Liver Neoplasms (etiology, virology)
  • Virus Replication

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