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Subglottic laryngeal paraganglioma.

AbstractOBJECTIVES:
To review the clinical and pathological picture of laryngeal paragangliomas and compare laryngeal paragangliomas with the three other types of laryngeal neuroendocrine neoplasms.
STUDY DESIGN:
The study presents a case review of a patient with a subglottic laryngeal paraganglioma treated at our institution, with a literature review of the laryngeal neuroendocrine neoplasms. Included is a review of all four neuroendocrine neoplasms, taking a close look at a comparison between laryngeal paragangliomas and atypical carcinoids tumors. All cases of subglottic laryngeal paragangliomas reported in the literature were also compiled and tabulated.
METHODS:
The patient's record was reviewed for age, symptomatology, workup, and surgical procedures performed.
RESULTS:
The patient was disease free 36 months after undergoing a tracheostomy for airway control, followed by a cricoid split for complete excision of the tumor.
CONCLUSIONS:
It is important to differentiate among the four laryngeal neuroendocrine neoplasms, especially between atypical carcinoids and paragangliomas. Each tumor requires different treatments, with the former requiring a more aggressive approach. Paragangliomas must be completely excised to prevent their recurrence, and this approach should be considered a curative treatment. In addition, the immunohistochemical battery is of paramount importance in obtaining the correct pathological diagnosis.
AuthorsRobert Maisel, Derek Schmidt, Stefan Pambuccian
JournalThe Laryngoscope (Laryngoscope) Vol. 113 Issue 3 Pg. 401-5 (Mar 2003) ISSN: 0023-852X [Print] United States
PMID12616186 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Keratins
  • Calcitonin
Topics
  • Aged
  • Calcitonin (metabolism)
  • Carcinoma, Neuroendocrine (metabolism, pathology, surgery)
  • Endoscopy (methods)
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Immunohistochemistry
  • Keratins (metabolism)
  • Laryngeal Neoplasms (metabolism, pathology, surgery)
  • Paraganglioma (metabolism, pathology, surgery)
  • Tracheal Neoplasms (metabolism, pathology, surgery)
  • Tracheostomy

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