False negative hydroxyamphetamine test in horner syndrome caused by acute internal carotid artery dissection.

• Abstract: A patient with Horner syndrome from internal carotid artery dissection initially had a false negative hydroxyamphetamine test. Two months later, the ophthalmic signs had disappeared but the hydroxyamphetamine test was positive. This case illustrates that hydroxyamphetamine testing may be falsely negative in acute Horner syndrome because norepinephrine stores in oculosympathetic postganglionic terminals have not yet been depleted. However, the hydroxyamphetamine test may be positive even after the ophthalmic signs of Horner syndrome have disappeared.
• Authors: Mark L Moster, David Galiani, William Garfinkle (Affiliation: Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, USA. mmoster at aol.com)
• Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society (J Neuroophthalmol) Vol. 23 Issue 1 Pg. 22-3 (Mar 2003) ISSN: 1070-8022 [Print] United States
• PMID: 12616084 (Publication Type: Case Reports, Journal Article)

Chemical References

• p-Hydroxyamphetamine
• Warfarin

Topics

• Adult
• Anisocoria (physiopathology)
• Carotid Arteries (surgery)
• Dissection (adverse effects)
• False Negative Reactions
• Hemorrhage (physiopathology)
• Horner Syndrome (diagnosis, etiology)
• Humans
• Magnetic Resonance Imaging
• Male
• Warfarin (therapeutic use)
• p-Hydroxyamphetamine (diagnostic use)