Abstract |
Two hundred and three human volunteers were tested for evidence of sensitization to several plasticizers following 3 weeks of dermal application three times a week. Tris(2-ethylhexyl)mellitate ( TOTM; 1%, v/v), 2,2,4-trimethyl-1,3-pentanediol-diisobutyrate (TXIB; 1%, v/v), di(2-ethylhexyl)terephthalate (DEHT; 0.5%, v/v) and diethylphthalate ( DEP; 2%, v/v) were applied to the skin of volunteers under semi-occlusive patch for 3 consecutive weeks and the reactions to a challenge application noted following a 2-week rest period. Slight erythema was observed in four individuals exposed to TOTM, two of which resolved within 96 h and one that occurred only after 96 h. Slight erythema was noted in three subjects exposed to TXIB, one of which resolved by 96 h and one that occurred only after 96 h. Two subjects had slight erythema to DEHT, one that resolved by 96 h and one that occurred only after 96 h. One reaction occurred with DEP at 96 h after challenge. Of the positive responses, one subject reacted to all test substances. No subject had a response grade of 1.0 or greater. Because of the low response, the overall conclusion is that none of the plasticizers demonstrated evidence of sensitization or irritation.
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Authors | R M David, L K Lockhart, K M Ruble |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 41
Issue 4
Pg. 589-93
(Apr 2003)
ISSN: 0278-6915 [Print] England |
PMID | 12615132
(Publication Type: Journal Article)
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Copyright | Copyright 2003 Elsevier Science Ltd. |
Chemical References |
- Benzoates
- Butyrates
- Glycols
- Irritants
- Phthalic Acids
- Plasticizers
- tri-(2-ethylhexyl)trimellitate
- 2,2,4-trimethyl-1,3-pentanediol diisobutyrate
- terephthalic acid
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Topics |
- Adolescent
- Adult
- Aged
- Benzoates
(adverse effects, toxicity)
- Butyrates
(adverse effects, toxicity)
- Dermatitis, Contact
(pathology)
- Erythema
(chemically induced, pathology)
- Female
- Glycols
(analysis, toxicity)
- Humans
- Irritants
(toxicity)
- Male
- Middle Aged
- Patch Tests
- Phthalic Acids
(adverse effects, toxicity)
- Plasticizers
(adverse effects, toxicity)
- Skin
(pathology)
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