Loniceroside C, an antiinflammatory saponin from Lonicera japonica.

Abstract

A new triterpenoid saponin, loniceroside C was isolated from the aerial parts of Lonicera japonica. Its structure was established to be 3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1-->2)-[beta-D-xylopyranosyl(1-->6)]-beta-D-glucopyranosyl ester by spectroscopic techniques and chemical transformations. Loniceroside C showed in vivo antiinflammatory activity against mouse ear edema provoked by croton oil.

• Authors: Wie Jong Kwak, Chang Kyun Han, Hyeun Wook Chang, Hyun Pyo Kim, Sam Sik Kang, Kun Ho Son
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 51 Issue 3 Pg. 333-5 (Mar 2003) ISSN: 0009-2363 [Print] Japan
• PMID: 12612424 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Glycosides
• Plant Extracts
• Saponins
• loniceracetalide A

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (chemistry, isolation & purification, therapeutic use)
• Edema (chemically induced, drug therapy)
• Glycosides
• Inflammation (chemically induced, drug therapy)
• Lonicera
• Male
• Mice
• Mice, Inbred ICR
• Plant Components, Aerial
• Plant Extracts (chemistry, isolation & purification, therapeutic use)
• Saponins (chemistry, isolation & purification, therapeutic use)