Abstract |
This randomized, double-blind, controlled trial evaluated the influence of low fat, low saturated fat food products that contained free tall oil-based phytosterols (TOP) and oat beta-glucan (from whole oats and bran concentrate) on serum lipid concentrations in adults with mild-to-moderate hypercholesterolemia. After a 5-wk National Cholesterol Education Program Step I diet lead-in period, 112 subjects incorporated one of two treatments into their diets for 6 wk: food products (cereal, snack bar and beverage) that provided 1.8 g TOP and 2.8 g beta-glucan/d and contained < or =3.0 g total fat and < or =1.0 g saturated fat (TOP/ beta-glucan treatment) or similar control foods. The serum LDL cholesterol response from baseline to the end of study was significantly larger in the TOP/ beta-glucan treated group than in the control group, in which there was no change (-3.7 vs. 0.4%; P = 0.013). Likewise, total cholesterol decreased in the TOP/ beta-glucan treatment group and did not change significantly in the controls (-2.3 vs. 0.8%; P = 0.043). Serum HDL cholesterol and triglyceride responses did not differ between the groups. The results of this trial suggest that consumption of a group of low fat, TOP and beta-glucan- containing foods is a useful adjunct in the dietary management of hypercholesterolemia.
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Authors | Kevin C Maki, Fred Shinnick, Marlyn A Seeley, Patricia E Veith, Laura C Quinn, Pamela J Hallissey, Arlene Temer, Michael H Davidson |
Journal | The Journal of nutrition
(J Nutr)
Vol. 133
Issue 3
Pg. 808-13
(Mar 2003)
ISSN: 0022-3166 [Print] United States |
PMID | 12612157
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Cholesterol, Dietary
- Cholesterol, HDL
- Cholesterol, LDL
- Dietary Fats
- Dietary Fiber
- Glucans
- Phytosterols
- Triglycerides
- Cholesterol
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Topics |
- Adult
- Aged
- Avena
(chemistry)
- Cholesterol
(blood)
- Cholesterol, Dietary
(administration & dosage)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Diet
- Diet Records
- Dietary Fats
(administration & dosage)
- Dietary Fiber
(administration & dosage)
- Double-Blind Method
- Female
- Glucans
(administration & dosage, adverse effects)
- Humans
- Hypercholesterolemia
(blood, diet therapy)
- Male
- Middle Aged
- Phytosterols
(administration & dosage, adverse effects)
- Triglycerides
(blood)
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