The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception.

Abstract

The present research studies the effects of sarmesin [Sar(1)Tyr(OMe)(4)] Angiotensin II (ANG II), an analogue of ANG II, on the seizure susceptibility, memory activity and nociception. It was found that this octapeptide, administered i.c.v., dose-dependently decreased the seizure intensity (pentylenetetrazol (PTZ) generalized seizure model and PTZ kindling) and augmented PTZ seizure threshold in mice. Sarmesin impaired the memory upon re-testing of rats 24 h later in the passive avoidance test. It decreased the pain threshold in a paw pressure nociceptive assay in rats. ANG II exerted pronociceptive effect as well. Taken together, these results reveal sarmesin as a behaviorally active peptide in the studied experimental animal models.

• Authors: J Tchekalarova, D Pechlivanova, T Kambourova, J Matsoukas, V Georgiev
• Journal: Regulatory peptides (Regul Pept) Vol. 111 Issue 1-3 Pg. 191-7 (Mar 28 2003) ISSN: 0167-0115 [Print] Netherlands
• PMID: 12609768 (Publication Type: Journal Article)
• Copyright: Copyright 2002 Elsevier Science B.V.

Chemical References

• Drug Combinations
• Imidazoles
• Pyridines
• Angiotensin II
• PD 123319
• angiotensin II, Sar(1)-Me-Tyr(4)-
• Losartan
• Pentylenetetrazole

Topics

• Angiotensin II (analogs & derivatives, pharmacology)
• Animals
• Avoidance Learning (drug effects)
• Disease Models, Animal
• Drug Combinations
• Imidazoles (pharmacology)
• Injections, Intraventricular
• Kindling, Neurologic
• Losartan (pharmacology)
• Male
• Memory (drug effects)
• Mice
• Pain Measurement (drug effects, methods)
• Pentylenetetrazole
• Pyridines (pharmacology)
• Seizures (chemically induced, prevention & control)
• Tail