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Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities.

Abstract
In a further study on the chemical constituents of Garcinia assigu, two new benzophenones corresponding to the 13-O-methyl ethers (1 and 2) of the known isogarcinol and garcinol, respectively, were isolated and characterized, along with known benzophenones (3-6). Inhibitory effects of the benzophenones isolated from this plant on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and their radical-scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were demonstrated. The cyclized polyprenylbenzophenones (1-5) showed comparable or stronger potential cancer chemopreventive activity when compared to glycyrrhetic acid, a known anti-tumor promoter.
AuthorsChihiro Ito, Masataka Itoigawa, Yoshiaki Miyamoto, Saori Onoda, K Sundar Rao, Teruo Mukainaka, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
JournalJournal of natural products (J Nat Prod) Vol. 66 Issue 2 Pg. 206-9 (Feb 2003) ISSN: 0163-3864 [Print] United States
PMID12608850 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Anticarcinogenic Agents
  • Antigens, Viral
  • Benzophenones
  • Biphenyl Compounds
  • Epstein-Barr virus early antigen
  • Free Radical Scavengers
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl
  • Tetradecanoylphorbol Acetate
  • Glycyrrhetinic Acid
Topics
  • Anticarcinogenic Agents (chemistry, isolation & purification, pharmacology)
  • Antigens, Viral (metabolism)
  • Benzophenones (chemistry, isolation & purification, pharmacology)
  • Biphenyl Compounds
  • Cyclization
  • Free Radical Scavengers (chemistry, isolation & purification, pharmacology)
  • Garcinia (chemistry)
  • Glycyrrhetinic Acid (pharmacology)
  • Humans
  • Lymphoma, B-Cell
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Papua New Guinea
  • Picrates
  • Plants, Medicinal (chemistry)
  • Tetradecanoylphorbol Acetate
  • Tumor Cells, Cultured (drug effects)

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