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Effect of fangchinoline in murine models of multiple organ dysfunction syndrome and septic shock.

AbstractOBJECTIVE AND DESIGN:
To study the effect of the alkaloid fangchinoline on zymosan-induced multiple organ dysfunction syndrome (MODS) and Escherichia coli (E. coli)-induced septic shock.
MATERIAL:
Male ICR mice were used. Macrophages were isolated from peritoneal cavity for in vitro study.
TREATMENT:
Fangchinoline was administered i.p. at a dose of 1 or 5 mg/kg into the mice.
METHODS:
MODS was induced by intraperitoneal (i.p.) injection of zymosan at a dose 1.0 or 0.8/g b.w. E. coli-induced septic shock was provoked by i.p. inoculation of 5 x 10(8) bacterial cells into mice. TNF-alpha in serum and supernatants from peritoneal macrophages was detected by the use of L-929 cell cytotoxic assay. Alternative pathway (AP) complement activity was determined by hemolytic assay.
RESULTS:
Fangchinoline increased the survival rate in lethal MODS and septic shock. The alkaloid prevented the loss of body weight and liver enlargement in MODS and suppressed serum tumor necrosis factor-alpha (TNF-alpha) accumulation in MODS and septic shock.
CONCLUSIONS:
The result suggest that fangchinoline due mainly to its ability to downregulate TNF-alpha production might have protective effect in murine models of zymosan-induced MODS and E. coli-induced septic shock.
AuthorsM Hristova, M Yordanov, N Ivanovska
JournalInflammation research : official journal of the European Histamine Research Society ... [et al.] (Inflamm Res) Vol. 52 Issue 1 Pg. 1-7 (Jan 2003) ISSN: 1023-3830 [Print] Switzerland
PMID12608643 (Publication Type: Journal Article)
Chemical References
  • Alkaloids
  • Benzylisoquinolines
  • Tumor Necrosis Factor-alpha
  • Complement System Proteins
  • Zymosan
  • fangchinoline
  • Alkaline Phosphatase
Topics
  • Alkaline Phosphatase (blood)
  • Alkaloids (therapeutic use)
  • Animals
  • Benzylisoquinolines
  • Complement System Proteins (biosynthesis)
  • Escherichia coli Infections (physiopathology)
  • Liver (drug effects, pathology)
  • Macrophages, Peritoneal (drug effects)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Multiple Organ Failure (chemically induced, drug therapy)
  • Organ Size (drug effects)
  • Shock, Septic (drug therapy)
  • Spleen (drug effects, pathology)
  • Time Factors
  • Tumor Necrosis Factor-alpha (analysis)
  • Zymosan

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