Abstract | OBJECTIVE AND DESIGN: MATERIAL: Male ICR mice were used. Macrophages were isolated from peritoneal cavity for in vitro study. TREATMENT:
Fangchinoline was administered i.p. at a dose of 1 or 5 mg/kg into the mice. METHODS:
MODS was induced by intraperitoneal (i.p.) injection of zymosan at a dose 1.0 or 0.8/g b.w. E. coli-induced septic shock was provoked by i.p. inoculation of 5 x 10(8) bacterial cells into mice. TNF-alpha in serum and supernatants from peritoneal macrophages was detected by the use of L-929 cell cytotoxic assay. Alternative pathway (AP) complement activity was determined by hemolytic assay. RESULTS: CONCLUSIONS:
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Authors | M Hristova, M Yordanov, N Ivanovska |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 52
Issue 1
Pg. 1-7
(Jan 2003)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 12608643
(Publication Type: Journal Article)
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Chemical References |
- Alkaloids
- Benzylisoquinolines
- Tumor Necrosis Factor-alpha
- Complement System Proteins
- Zymosan
- fangchinoline
- Alkaline Phosphatase
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Topics |
- Alkaline Phosphatase
(blood)
- Alkaloids
(therapeutic use)
- Animals
- Benzylisoquinolines
- Complement System Proteins
(biosynthesis)
- Escherichia coli Infections
(physiopathology)
- Liver
(drug effects, pathology)
- Macrophages, Peritoneal
(drug effects)
- Male
- Mice
- Mice, Inbred ICR
- Multiple Organ Failure
(chemically induced, drug therapy)
- Organ Size
(drug effects)
- Shock, Septic
(drug therapy)
- Spleen
(drug effects, pathology)
- Time Factors
- Tumor Necrosis Factor-alpha
(analysis)
- Zymosan
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