[Interferon-based immunobiological preparations. An outlook of their use in the treatment of patients with infections].

Abstract

The paper contains the generalizing results of many-year research related with using various ready-made medication forms (RMF) of human genetic-engineering interferon-alpha 2 and of methods of its administration into the body. Extensive clinical materials were made use of to show convincingly that the most effective therapy for infectious diseases is ensured within a short time period and with a consequent long-term rehabilitation effect by using separate RMFs and methods of application of interferon-alpha 2, when their impact on the lesion focus is monitored by the parameters of the cellular-and-humoral chains of the general and local immunity. It is noteworthy, that a selection of RMF adequate for an actual nosologic form or of an administration method can reduce the medication dose of interferon-alpha 2 (thus, the incidence of complications to the drug goes down), it can also eliminate the influenza-like syndrome and production of autoantibodies related with the intramuscular administration of interferon-alpha 2, besides, it essentially prolongs the presence of interferon-alpha 2 in the body. It is important that the application of interferon-based preparations for infectious diseases can eliminate, in a number of cases, the use of antibiotics and other antibacterial drugs, it enhances the efficacy of antibacterial and antiviral therapy within a comprehensive treatment scheme, it contributes to a higher resistance of normal flora to the action of antibiotic and antibacterial drugs, and, finally, it arrests quicker the manifestations of dysbacterioses of various localizations.

• Authors: S S Afanas'ev, V A Aleshkin, L V Feklisova, O V Rubal'skiĭ, V Iu Davydkin
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 1 Pg. 44-8 ( 2003) ISSN: 0869-6047 [Print] Russia (Federation)
• Vernacular Title: Interferonovye immunobiologicheskie preparaty. Perspektivy ikh primeneniia v lechenii infektsionnykh bol'nykh.
• PMID: 12608085 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Antitubercular Agents
• Immunologic Factors
• Interferon-alpha
• Suppositories

Topics

• Administration, Inhalation
• Administration, Oral
• Adolescent
• Adult
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Antitubercular Agents (administration & dosage, therapeutic use)
• Arthritis, Rheumatoid (drug therapy)
• Bronchitis (drug therapy)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Drug Therapy, Combination
• Female
• Humans
• Immunologic Factors (administration & dosage)
• Infant
• Infections (drug therapy)
• Injections, Intramuscular
• Interferon-alpha (administration & dosage)
• Intestinal Diseases (drug therapy)
• Male
• Middle Aged
• Pharyngitis (drug therapy)
• Protein Engineering
• Recurrence
• Research
• Respiratory Tract Infections (drug therapy)
• Suppositories
• Time Factors
• Tuberculosis, Pulmonary (drug therapy)