Satoyoshi syndrome in a Caucasian girl improved with glucocorticoids--a clinical report.

Abstract

Satoyoshi syndrome (OMIM 600705) is a rare disorder of unknown cause characterized by progressive painful intermittent muscle spasms, amenorrhea, alopecia, malabsorption, and skeletal abnormalities mimicking a skeletal dysplasia. In this report, we describe a Caucasian 12-year-old girl that presented with characteristic manifestations, including alopecia, muscle cramps, and short stature with onset at age 7. Prednisone 60 mg/m(2) every other day and amytriptiline 25 mg QD were administered. After 2 months, alopecia had significantly improved and muscle cramps had almost disappeared, so that glucocorticoid treatment was tapered. Follow-up, 9 months later, showed a normal looking and asymptomatic girl.

• Authors: Cláudia Rafaela Cecchin, Têmis Maria Félix, Richard B Magalhães, Tânia Weber Furlanetto
• Journal: American journal of medical genetics. Part A (Am J Med Genet A) Vol. 118A Issue 1 Pg. 52-4 (Apr 01 2003) ISSN: 1552-4825 [Print] United States
• PMID: 12605441 (Publication Type: Journal Article)
• Copyright: Copyright 2003 Wiley-Liss, Inc.

Chemical References

• Glucocorticoids
• Prednisone

Topics

• Abnormalities, Multiple (drug therapy, genetics)
• Child
• Female
• Glucocorticoids (pharmacology)
• Humans
• Prednisone (pharmacology)