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[Successful treatment of haemodialysis-related porphyria cutanea tarda with deferoxamine].

AbstractBACKGROUND:
End-stage renal failure and long-term hemodialysis treatment promote porphyria cutanea tarda. Iron overload is often associated with this disease and is thought to play a role in its pathogenesis. We report a case of hemodialysis related-porphyria cutanea tarda improved by deferoxamine.
CASE REPORT:
A 45-year-old man, with end-stage renal failure and who had received hemodialysis treatment since 1993, presented a several months-history of blisters of the face and the dorsum of the hands. Laboratory analysis showed: hemoglobin 10 g/dl; a moderate hepatic cytolysis; ferritin 195 ng/l. HIV, HBV, HCV serologies were negative. Porphyries analyses showed a porphyria cutanea tarda pattern. The cutaneous histology was non specific; direct immunofluorescence was negative. The patient received deferoxamine (40 mg/kg intravenously every week for 6 weeks) which led to dramatic improvement of the symptoms.
DISCUSSION:
Several treatments are proposed in the management of dialysis-related porphyria cutanea tarda. This case confirms that deferoxamine can induce rapid and prolonged remission.
AuthorsP Pitche, E Corrin, P Wolkenstein, J Revuz, M Bagot
JournalAnnales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 130 Issue 1 Pt 1 Pg. 37-9 (Jan 2003) ISSN: 0151-9638 [Print] France
Vernacular TitlePorphyrie cutanée tardive chez l'hémodialysé. Un cas sévère traité efficacement par déféroxamine.
PMID12605155 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Iron Chelating Agents
  • Deferoxamine
Topics
  • Deferoxamine (therapeutic use)
  • Humans
  • Iron Chelating Agents (therapeutic use)
  • Male
  • Middle Aged
  • Porphyria Cutanea Tarda (drug therapy, etiology)
  • Remission Induction
  • Renal Dialysis (adverse effects)

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