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Biological and environmental factors affecting ultrasound-induced hemolysis in vitro: 2. Medium dissolved gas (pO2) content.

Abstract
The data collected in this project supported the a priori hypothesis that the concentration of dissolved oxygen in whole human blood in vitro affected the extent of ultrasound (US)-induced hemolysis under conditions conducive to the occurrence of inertial cavitation. Aliquots of whole human blood in vitro with a relatively high O(2) level had statistically significantly more 1-MHz US-induced hemolysis than aliquots with a relatively low O(2) level in the presence of controlled gas nucleation (Albunex or ALX, supplementation), with US-induced hemolytic yields being substantially less at 2.2- and 3.5-MHz exposures or in the absence of ALX-supplementation at otherwise comparable acoustic pressures, pulse lengths and duty factors. Passive cavitation detection (pcd) measures indicated a linear relationship for hemolysis up to about 70% and pcd values (R(2) = 0.99).
AuthorsMorton W Miller, E Carr Everbach, W Marcus Miller, Linda F Battaglia
JournalUltrasound in medicine & biology (Ultrasound Med Biol) Vol. 29 Issue 1 Pg. 93-102 (Jan 2003) ISSN: 0301-5629 [Print] England
PMID12604120 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
CopyrightCopyright 2003 World Federation for Ultrasound in Medicine & Biology
Chemical References
  • Albumins
  • Albunex
  • Contrast Media
  • Oxygen
Topics
  • Albumins (pharmacology)
  • Contrast Media (pharmacology)
  • Erythrocytes (diagnostic imaging)
  • Hemolysis (drug effects)
  • Humans
  • In Vitro Techniques
  • Oxygen (blood)
  • Pressure
  • Temperature
  • Ultrasonography

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