Abstract |
The data collected in this project supported the a priori hypothesis that the concentration of dissolved oxygen in whole human blood in vitro affected the extent of ultrasound (US)-induced hemolysis under conditions conducive to the occurrence of inertial cavitation. Aliquots of whole human blood in vitro with a relatively high O(2) level had statistically significantly more 1-MHz US-induced hemolysis than aliquots with a relatively low O(2) level in the presence of controlled gas nucleation ( Albunex or ALX, supplementation), with US-induced hemolytic yields being substantially less at 2.2- and 3.5-MHz exposures or in the absence of ALX-supplementation at otherwise comparable acoustic pressures, pulse lengths and duty factors. Passive cavitation detection (pcd) measures indicated a linear relationship for hemolysis up to about 70% and pcd values (R(2) = 0.99).
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Authors | Morton W Miller, E Carr Everbach, W Marcus Miller, Linda F Battaglia |
Journal | Ultrasound in medicine & biology
(Ultrasound Med Biol)
Vol. 29
Issue 1
Pg. 93-102
(Jan 2003)
ISSN: 0301-5629 [Print] England |
PMID | 12604120
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2003 World Federation for Ultrasound in Medicine & Biology |
Chemical References |
- Albumins
- Albunex
- Contrast Media
- Oxygen
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Topics |
- Albumins
(pharmacology)
- Contrast Media
(pharmacology)
- Erythrocytes
(diagnostic imaging)
- Hemolysis
(drug effects)
- Humans
- In Vitro Techniques
- Oxygen
(blood)
- Pressure
- Temperature
- Ultrasonography
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