Abstract |
The pharmacokinetic behavior of marbofloxacin was studied in seven healthy goats and in the same goats with induced fever after single-dose intravenous (i.v.) administration of 2 mg/kg b.w. Fever was induced by the administration of Escherichia coli endotoxin. Drug concentration in plasma was determined by high-performance liquid chromatography (HPLC). Drug distribution was somehow altered by fever as febrile goats showed a volume of distribution at steady-state (Vss = 0.72 +/- 0.15 L/kg) lower than normal goats (Vss = 1.19 +/- 0.33 L/kg). The elimination of the drug was also modified. Total plasma clearance (Cl) decreased from 0.24 +/- 0.12 L/kg/h in healthy animals to 0.13 +/- 0.05 L/kg/h in animals with endotoxin-induced fever, which is related to an increase in the area under the plasma concentration-time curve (AUC). Consequently, mean residence time (MRT) was also slightly increased in sick animals (MRT = 5.28 +/- 00.99 and 6.09 +/- 01.45 h, in healthy and febrile animals, respectively).
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Authors | S Waxman, M D San Andrés, F González, J J De Lucas, M I San Andrés, C Rodríguez |
Journal | Journal of veterinary pharmacology and therapeutics
(J Vet Pharmacol Ther)
Vol. 26
Issue 1
Pg. 65-9
(Feb 2003)
ISSN: 0140-7783 [Print] England |
PMID | 12603777
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Endotoxins
- Fluoroquinolones
- Quinolones
- Topoisomerase II Inhibitors
- marbofloxacin
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Topics |
- Animals
- Anti-Infective Agents
(administration & dosage, blood, pharmacokinetics)
- Area Under Curve
- Chromatography, High Pressure Liquid
- Endotoxins
- Escherichia coli
- Female
- Fever
(metabolism, veterinary)
- Fluoroquinolones
- Goat Diseases
(metabolism)
- Goats
(metabolism)
- Injections, Intravenous
(veterinary)
- Quinolones
(administration & dosage, blood, pharmacokinetics)
- Topoisomerase II Inhibitors
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