Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats.

Abstract

1 The pharmacokinetics of the lithium ion administered as lithium orotate were studied in rats. Parallel studies were carried out with lithium carbonate and lithium chloride. 2 No differences in the uptake, distribution and excretion of the lithium ion were observed between lithium orotate, lithium carbonate and lithium chloride after single intraperitoneal, subcutaneous or intragastric injections (0.5-1.0 mEq lithium/kg) or after administration of the lithium salts for 20 days in the food. 3 The findings oppose the notion that the pharmacokinetics of the lithium ion given as lithium orotate differ from lithium chloride or lithium carbonate. 4 Polyuria and polydipsia developed more slowly in rats given lithium orotate than in those given lithium carbonate or lithium chloride, perhaps due to an effect of the orotate anion.

• Authors: D F Smith
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 56 Issue 4 Pg. 399-402 (Apr 1976) ISSN: 0007-1188 [Print] England
• PMID: 1260219 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Carbonates
• Chlorides
• Orotic Acid
• Lithium

Topics

• Animals
• Carbonates (metabolism, pharmacology)
• Chlorides (metabolism, pharmacology)
• Drinking Behavior (drug effects)
• Kinetics
• Lithium (metabolism, pharmacology)
• Male
• Orotic Acid (metabolism, pharmacology)
• Rats
• Stimulation, Chemical
• Urination (drug effects)