HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Ameliorative effects of histamine on 7-chlorokynurenic acid-induced spatial memory deficits in rats.

AbstractRATIONALE:
Histamine plays an important role in modulating acquisition and retention in learning and memory process in experimental animals.
OBJECTIVES:
We examined the effects of polyamine and histamine on the N-methyl- d-aspartate (NMDA) receptor glycine site antagonist 7-chlorokynurenic acid-induced spatial memory deficits in radial maze performance in rats.
METHOD:
Effects of histamine (0.5 or 1 nmol/site intracerebroventricularly), spermidine (1 nmol/site, intracerebroventricularly) and spermine (1 nmol/site, intracerebroventricularly) on spatial memory deficit in 9-week-old-male Wistar rats were observed. Both reference and working memory errors occurred in radial maze performance in rats, following intracerebroventricular injection of 7-chlorokynurenic acid (10 nmol/site).
RESULTS:
Spermidine (1 nmol/site, intracerebroventricularly) or spermine (1 nmol/site, intracerebroventricularly) antagonized 7-chlorokynurenic acid-induced deficits on working memory but not on reference memory errors. Intracerebroventricular histamine (0.5 or 1 nmol/site) or thioperamide (100 nmol/site) also ameliorated 7-chlorokynurenic acid-induced working memory deficits. To determine whether the effects of histamine involve histamine receptors, the effects of some methylhistamines were examined. The effects of R-alpha-methylhistamine on radial maze performance were mimicked by histamine. N(alpha)-methylhistamine had no effect on 7-chlorokynurenic acid-induced memory deficits, whereas 1-methylhistamine, but not 3-methylhistamine reversed 7-chlorokynurenic acid-induced working memory deficits.
CONCLUSION:
These results suggest that the amelioration of 7-chlorokynurenic acid-induced working memory deficits by histamine may involve a direct action of histamine at the polyamine sites on NMDA receptors.
AuthorsMiyuki Nishiga, Chiaki Kamei
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 166 Issue 4 Pg. 360-5 (Apr 2003) ISSN: 0033-3158 [Print] Germany
PMID12601505 (Publication Type: Journal Article)
Chemical References
  • Excitatory Amino Acid Antagonists
  • Methylhistamines
  • Polyamines
  • Receptors, N-Methyl-D-Aspartate
  • Spermine
  • Histamine
  • Kynurenic Acid
  • 7-chlorokynurenic acid
  • Spermidine
Topics
  • Animals
  • Excitatory Amino Acid Antagonists (toxicity)
  • Histamine (pharmacology)
  • Kynurenic Acid (analogs & derivatives, antagonists & inhibitors, toxicity)
  • Male
  • Memory Disorders (chemically induced)
  • Methylhistamines (pharmacology)
  • Motor Activity (drug effects)
  • Polyamines (pharmacology)
  • Rats
  • Rats, Wistar
  • Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors)
  • Spermidine (pharmacology)
  • Spermine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: