Abstract | RATIONALE:
Histamine plays an important role in modulating acquisition and retention in learning and memory process in experimental animals. OBJECTIVES: METHOD: Effects of histamine (0.5 or 1 nmol/site intracerebroventricularly), spermidine (1 nmol/site, intracerebroventricularly) and spermine (1 nmol/site, intracerebroventricularly) on spatial memory deficit in 9-week-old-male Wistar rats were observed. Both reference and working memory errors occurred in radial maze performance in rats, following intracerebroventricular injection of 7-chlorokynurenic acid (10 nmol/site). RESULTS: CONCLUSION:
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Authors | Miyuki Nishiga, Chiaki Kamei |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 166
Issue 4
Pg. 360-5
(Apr 2003)
ISSN: 0033-3158 [Print] Germany |
PMID | 12601505
(Publication Type: Journal Article)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Methylhistamines
- Polyamines
- Receptors, N-Methyl-D-Aspartate
- Spermine
- Histamine
- Kynurenic Acid
- 7-chlorokynurenic acid
- Spermidine
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Topics |
- Animals
- Excitatory Amino Acid Antagonists
(toxicity)
- Histamine
(pharmacology)
- Kynurenic Acid
(analogs & derivatives, antagonists & inhibitors, toxicity)
- Male
- Memory Disorders
(chemically induced)
- Methylhistamines
(pharmacology)
- Motor Activity
(drug effects)
- Polyamines
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, N-Methyl-D-Aspartate
(antagonists & inhibitors)
- Spermidine
(pharmacology)
- Spermine
(pharmacology)
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