Abstract | AIMS AND BACKGROUND: METHODS: Mammary tumor xenografts induced using BT474 cells, a breast carcinoma cell line showing overexpression of C-erbB-2, were used for immunoscintigraphic studies. RESULTS: Scintigrams showed high radiolabel uptake by the tumor tissue of the mice belonging to the experimental group, whereas in control animals no radiolabel uptake was visualized. Biodistribution studies correlated well with scintiscans. CONCLUSIONS:
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Authors | Ananthanarayanan Meenakshi, Rayala Suresh Kumar, Venkatraman Ganesh, Nallathambi Siva Kumar |
Journal | Tumori
(Tumori)
2002 Nov-Dec
Vol. 88
Issue 6
Pg. 507-12
ISSN: 0300-8916 [Print] United States |
PMID | 12597148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- CIBCgp185 monoclonal antibody
- Radiopharmaceuticals
- Technetium
- Receptor, ErbB-2
|
Topics |
- Animals
- Antibodies, Monoclonal
(analysis)
- Breast Neoplasms
(chemistry, diagnostic imaging)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
(methods)
- Mice
- Mice, Nude
- Radioimmunodetection
(methods)
- Radiopharmaceuticals
- Receptor, ErbB-2
(analysis, immunology)
- Technetium
- Tumor Cells, Cultured
- Up-Regulation
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