[The expression of FN-IIIcs in the wound healing and its relationship with injury time].

Abstract

OBJECTIVE:

To research the expression of alternative splicing segment of fibronectin-IIIcs in incised wound of skin, to offer the experimental data for early injury time judgement.

METHODS:

Using in situ hybridization with DIG-labeled anti-sense RNA probe, the expression of FN-IIIcs domain was detected in both human and rat skin incised wound.

RESULTS:

(1) The expression of FN-IIIcs improved from the time of 30 min after injury, reached peak at 6 h and then reduced gradually. (2) The positive expression cells were mainly distributed in hair follicles, sebaceous glands and endothelium, however, in human beings they were basement cells of epidermis.

CONCLUSION:

The expression of FN-IIIcs domain would be a supposed useful criteria for early injury time judgement.

• Authors: Yan Ji, Zi-qin Zhao, Yun-ju Gu
• Journal: Fa yi xue za zhi (Fa Yi Xue Za Zhi) Vol. 18 Issue 1 Pg. 4-6 (Feb 2002) ISSN: 1004-5619 [Print] China
• PMID: 12596577 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibronectins
• RNA, Messenger

Topics

• Animals
• Fibronectins (biosynthesis, genetics)
• Forensic Medicine
• Humans
• Male
• RNA, Messenger (biosynthesis)
• Rats
• Rats, Sprague-Dawley
• Skin (injuries, metabolism)
• Time Factors
• Wound Healing (physiology)