Comparison of antiallergic drugs in an experimental model of ocular anaphylaxis.

Abstract

PURPOSE:

To compare the efficacy of antiallergic drugs in an experimental ocular anaphylaxis model.

MATERIALS AND METHODS:

Fifty-two rats were divided into 8 groups. Dithiothreitol and ovalbumin (OVA) were applied to both eyes of previously OVA-inoculated rats in groups 1-5 and 7. In groups 1-5, antiallergic efficacy of the drugs (lodoxamide, sodium cromoglycate, levacobastine, cimetidine, and diclofenac sodium) instilled on the right eyes were compared with the buffer instilled on the left eyes, measuring the amount of extravasated Evans blue (EB) dye by spectrophotometric analysis. Group 6 served as a control of EB dye extravasations in nonimmunized eyes. Histopathologic examinations for anaphylaxis and controls were done in groups 7 and 8.

RESULTS:

Only levacobastine and lodoxamide decreased vascular permeability at a significant ratio (46%, p < 0.01 and 31%, p < 0.05, respectively).

CONCLUSION:

Levacobastine and lodoxamide but none of the three other drugs mentioned above were found to be effective in decreasing vascular permeability.

• Authors: Atilla Bayer, H Avni Uludağ, Güngör Sobaci, Fatih Mehmet Mutlu
• Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde (Ophthalmologica) 2003 Mar-Apr Vol. 217 Issue 2 Pg. 119-23 ISSN: 0030-3755 [Print] Switzerland
• PMID: 12592050 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2003 S. Karger AG, Basel

Chemical References

• Anti-Allergic Agents
• Ophthalmic Solutions
• Ovalbumin
• Dithiothreitol

Topics

• Anaphylaxis (chemically induced, drug therapy, pathology)
• Animals
• Anti-Allergic Agents (therapeutic use)
• Capillary Permeability (drug effects)
• Conjunctiva (blood supply, drug effects)
• Conjunctivitis, Allergic (chemically induced, drug therapy, pathology)
• Disease Models, Animal
• Dithiothreitol
• Male
• Ophthalmic Solutions
• Ovalbumin
• Rats
• Rats, Wistar