Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides.

Abstract

The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid beta-peptides (Abeta) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.

• Authors: Javier Sáez-Valero, Lisa R Fodero, Anthony R White, Colin J Barrow, David H Small
• Journal: Brain research (Brain Res) Vol. 965 Issue 1-2 Pg. 283-6 (Mar 07 2003) ISSN: 0006-8993 [Print] Netherlands
• PMID: 12591148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Peptide Fragments
• amyloid beta-protein (1-42)
• amyloid beta-protein (25-35)
• Acetylcholinesterase

Topics

• Acetylcholinesterase (biosynthesis)
• Amyloid beta-Peptides (pharmacology)
• Animals
• Astrocytes (drug effects, enzymology)
• Cells, Cultured
• Cerebral Cortex (cytology, drug effects, physiology)
• Embryo, Mammalian
• Mice
• Mice, Inbred C57BL
• Neurons (drug effects, enzymology)
• Peptide Fragments (pharmacology)