Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients.

Abstract

Visualisation of primary prostate cancer, its relapse and its metastases is a clinically relevant problem despite the availability of state-of-the-art methods such as CT, MRI, transrectal ultrasound and fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET). The aim of this study was to evaluate the efficacy of carbon-11 acetate and (18)F-FDG PET in the detection of prostate cancer and its metastases. Twenty-five patients were investigated during the follow-up of primary prostate cancer, suspected relapse or metastatic disease using (11)C-acetate PET; 15 of these patients were additionally investigated using (18)F-FDG PET. Fourteen patients were receiving anti-androgen treatment at the time of the investigation. Lesions were detected in 20/24 (83%) patients using (11)C-acetate PET and in 10/15 (75%) patients using (18)F-FDG PET. Based on the results of both PET scans, one patient was diagnosed with recurrent lung cancer. Median (18)F-FDG uptake exceeded that of (11)C-acetate in distant metastases (SUV =3.2 vs 2.3). However, in local recurrence and in regional lymph node metastases, (11)C-acetate uptake (median SUVs =2.9 and 3.8, respectively) was higher than that of (18)F-FDG (median SUVs =1.0 and 1.1, respectively). A positive correlation was observed between serum PSA level and both (11)C-acetate uptake and (18)F-FDG uptake. (11)C-acetate seems more useful than (18)F-FDG in the detection of local recurrences and regional lymph node metastases. (18)F-FDG, however, appears to be more accurate in visualising distant metastases. There may be a role for combined (11)C-acetate/(18)F-FDG PET in the follow-up of patients with prostate cancer and persisting or increasing PSA.

• Authors: E Fricke, S Machtens, M Hofmann, J van den Hoff, S Bergh, T Brunkhorst, G J Meyer, J H Karstens, W H Knapp, A R Boerner
• Journal: European journal of nuclear medicine and molecular imaging (Eur J Nucl Med Mol Imaging) Vol. 30 Issue 4 Pg. 607-11 (Apr 2003) ISSN: 1619-7070 [Print] Germany
• PMID: 12589476 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Acetates
• Radiopharmaceuticals
• carbon-11 acetate
• Fluorodeoxyglucose F18
• Carbon
• Prostate-Specific Antigen

Topics

• Acetates
• Aged
• Aged, 80 and over
• Bone Neoplasms (blood, diagnostic imaging, secondary)
• Carbon
• Fluorodeoxyglucose F18
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local (blood, diagnostic imaging)
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (blood, diagnostic imaging, pathology)
• Radiopharmaceuticals
• Reproducibility of Results
• Sensitivity and Specificity
• Tomography, Emission-Computed (methods)