[Argon plasma coagulation and topically applied estriol. Long-term results in the treatment of hereditary hemorrhagic telangiectasia of the nasal mucosa].

Abstract

BACKGROUND AND OBJECTIVE:

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant fibrovascular dysplasia with the main symptom of recurrent epistaxis. At present, only limited data are available on long-term results in the treatment of epistaxis. A part from the surgical treatment of the bleeding telangiectasia with argon plasma, an additional postoperative long-term treatment with estriol nose-ointment was performed and the results were analysed.

PATIENTS AND METHODS:

69 patients with HHT were treated with APC and estriol nose ointment. 43 patients could be examined over a follow-up period of more than 20 months. The bleeding frequency and intensity as well as the patient's satisfaction with the treatment result were evaluated and the serum estriol level determined.

RESULTS:

After more than 20 months, the bleeding frequency and intensity were reduced in 95% of the patients compared to their preoperative findings. Under the influence of estriol, former berry-like telangiectasias became flatter and more even. Neither systemic side effects under topically applied estriol nor a relevant increase of serum estriol levels were observed.

CONCLUSION:

The combined treatment regimen with APC and topically applied estriol provides a new treatment concept of epistaxis in HHT.

• Authors: H Sadick, F Riedel, J Oulmi, K Hörmann, W F Bergler
• Journal: HNO (HNO) Vol. 51 Issue 2 Pg. 118-24 (Feb 2003) ISSN: 0017-6192 [Print] Germany
• Vernacular Title: Argonplasmachirurgie und topische Estriolapplikation. Langzeitergebnisse in der Behandlung von hereditären hämorrhagischen Teleangiektasien der Nasenschleimhaut.
• PMID: 12589417 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Estriol

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Child
• Combined Modality Therapy
• Epistaxis (genetics, therapy)
• Estriol (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Laser Coagulation
• Male
• Middle Aged
• Nasal Mucosa (blood supply)
• Patient Satisfaction
• Postoperative Care
• Telangiectasia, Hereditary Hemorrhagic (genetics, therapy)