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Beneficial effects of a glyburide/metformin combination preparation in type 2 diabetes mellitus.

AbstractBACKGROUND:
Type 2 diabetes mellitus is characterized by both insulin deficiency and insulin resistance. Effective treatment often requires therapy directed at both abnormalities. Patients on monotherapy might benefit from a combination agent such as glyburide/metformin, which increases insulin secretion and reduces insulin resistance.
METHODS:
All patients taking a glyburide/metformin preparation at the Carl T. Hayden VAMC were identified from pharmacy records. Patients with documented hemoglobin A values within 31 weeks prior and between 3 and 33 weeks after initiation of therapy (92 subjects) were examined.
RESULTS:
Glyburide/metformin combination therapy reduced hemoglobin A levels from 0.087 to 0.083 (P < 0.06). Significant reductions were seen in those patients with initial levels higher than 0.08 (0.094 to 0.087; P < 0.01). No significant reductions were seen in those patients with initial levels lower than 0.08.
CONCLUSIONS:
In patients on monotherapy or on dual oral therapy with inadequate control, changing to a glyburide/metformin combination preparation may improve glucose control.
AuthorsSyed U Bokhari, Usha M Gopal, William C Duckworth
JournalThe American journal of the medical sciences (Am J Med Sci) Vol. 325 Issue 2 Pg. 66-9 (Feb 2003) ISSN: 0002-9629 [Print] United States
PMID12589230 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Blood Glucose
  • Drug Combinations
  • Glucovance
  • Hypoglycemic Agents
  • Insulin
  • Hemoglobin A
  • Metformin
  • Glyburide
Topics
  • Blood Glucose (metabolism)
  • Diabetes Mellitus, Type 2 (drug therapy)
  • Drug Combinations
  • Glyburide (therapeutic use)
  • Hemoglobin A (metabolism)
  • Humans
  • Hypoglycemic Agents (therapeutic use)
  • Insulin (metabolism)
  • Insulin Resistance (physiology)
  • Metformin (therapeutic use)

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