Ambisome (
L-Amb) was used to treat nine cases of
meningitis or menigoencephalitis by Cryptococcus neoformans and 28 cases of other deep
fungal infections. A retrospective study on conventional
amphotericin B (C-Amb) was performed as the control. A series of indices was observed including curative effect, fungal clearance rate, course of treatment, daily dose, cumulative dose and adverse effects. Nine cases of
cryptococcal meningitis or menigoencephalitis treated with
Ambisome were clinically cured with an effective rate of 100%, within a mean course of 50 days, which was shorter than that of C-Amb, by a mean cumulative dose of 1807.2 mg, which was not statistically significant in comparison with C-Amb. Fungal clearance rate on the second month of treatment was 89% with
Ambisome, which was higher than that of C-Amb. Twenty-eight cases of other deep
fungal infections treated with
Ambisome were clinically cured with an effective rate of 92%, within a mean course of 19.3 days, by a mean cumulative dose of 907.5 mg, and fungal clearance rate on the second and third month was 75 and 92%, respectively. The adverse effects by
Ambisome decreased evidently compared with those by C-Amb.