On biologically conformal boost dose optimization.

Abstract

A method is described that allows the inclusion of biological imaging data in the optimization of intensity-modulated radiotherapy to produce dose boosts that conform with target subvolumes of potentially reduced radiosensitivity. The biological image (e.g. PET, fMRI, etc) is transformed into a dose efficiency distribution using a piecewise linear calibration function with a prescribed maximum boost factor. Instead of dose alone, the cost function of the optimization algorithm depends on the product of the physical dose times dose efficiency. An example case of a base-of-tongue tumour which was imaged with the hypoxia tracer fluoro-misonidazole is presented, showing the excellent capability of IMRT to produce dose distributions that conform to spatially variable dose prescriptions.

• Authors: M Alber, F Paulsen, S M Eschmann, H J Machulla
• Journal: Physics in medicine and biology (Phys Med Biol) Vol. 48 Issue 2 Pg. N31-5 (Jan 21 2003) ISSN: 0031-9155 [Print] England
• PMID: 12587912 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• fluoromisonidazole
• Misonidazole

Topics

• Algorithms
• Imaging, Three-Dimensional (methods)
• Misonidazole (analogs & derivatives, pharmacokinetics)
• Quality Control
• Radiometry (methods)
• Radiotherapy Dosage
• Radiotherapy Planning, Computer-Assisted
• Radiotherapy, Conformal (methods)
• Tomography, Emission-Computed (methods)
• Tongue Neoplasms (diagnostic imaging, metabolism, radiotherapy)