[Effect of "yang wei kang liu" granula on expression of P53 and PCNA in mice bearing sarcoma 180].

Abstract

OBJECTIVE:

To study possible mechanism of "Yang Wei Kang Liu" (YWKL) granula in treating tumor.

METHODS:

Mice bearing sarcoma180 and immunohisto-chemical method were adopted.

RESULTS:

Both YWKL granula and its cooperated chemothrapy could restrain the expression of P53 and PCNA. Compared with the chemotherapy group and the cooperated chemotherapy, YWKL granula group was significantly different.

CONCLUSION:

YWKL granula could restrain the expression of P53 and PCNA, and increase the effect together with chemotherapy.

• Authors: Y Cai, G Sun
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 24 Issue 4 Pg. 285-6 (Apr 2001) ISSN: 1001-4454 [Print] China
• PMID: 12587164 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Proliferating Cell Nuclear Antigen
• Tumor Suppressor Protein p53
• yang wei kang liu

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Mice
• Proliferating Cell Nuclear Antigen (metabolism)
• Sarcoma 180 (immunology, metabolism)
• Tumor Suppressor Protein p53 (metabolism)