Abstract | BACKGROUND: METHODS: RESULTS:
IL-6 decreased ( p =.03) over time for the T and P groups when compared to the RT+T and RT+P groups. A time effect ( p =.013) was observed for TNF alpha with Mid and Post both being lower than Pre. A hormone by time interaction ( p =.03) was observed for plasma leptin with individuals not on T exhibiting higher concentrations Post than those individuals on T. A positive correlation was observed (r =.60; p <.05) between changes in fat mass and the change in leptin. CONCLUSION:
IL-6 was reduced by MA except when RT was undertaken; TNF alpha was reduced over time regardless of group; leptin was higher in individuals not on T than those on T; and the change in plasma leptin was correlated with the change in fat mass.
|
Authors | Charles P Lambert, Dennis H Sullivan, William J Evans |
Journal | The journals of gerontology. Series A, Biological sciences and medical sciences
(J Gerontol A Biol Sci Med Sci)
Vol. 58
Issue 2
Pg. 165-70
(Feb 2003)
ISSN: 1079-5006 [Print] United States |
PMID | 12586855
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Interleukin-6
- Leptin
- Tumor Necrosis Factor-alpha
- Testosterone
- Megestrol Acetate
|
Topics |
- Aged
- Analysis of Variance
- Appetite
(drug effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Enzyme-Linked Immunosorbent Assay
- Exercise
(physiology)
- Humans
- Injections, Intramuscular
- Interleukin-6
(analysis, metabolism)
- Leptin
(analysis, metabolism)
- Male
- Megestrol Acetate
(administration & dosage)
- Middle Aged
- Physical Education and Training
- Probability
- Reference Values
- Sensitivity and Specificity
- Testosterone
(administration & dosage)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(analysis, metabolism)
- Weight Gain
(drug effects)
|