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[Relationship between serum load of HBV-DNA and therapeutic effect of oxymatrine in patients with chronic hepatitis B].

AbstractOBJECTIVE:
To study the relationship between serum load level of HBV-DNA and therapeutic effect of oxymatrine in patients with chronic hepatitis B.
METHODS:
Forty-four patients of chronic hepatitis B were divided into two groups, the treated group was treated with oxymatrine 0.4 g/d by intramuscular injection for 3 months, the control group was treated with some liver protecting agents to estimate the therapeutic effect. The serum level of HBV-DNA was determined by quantitative polymerase chain reaction (PCR) before and after treatment.
RESULTS:
The seroconversion rate of HBV-DNA and HBeAg in the treated group was 43.47% and 43.47% respectively, which was obviously better than those in the control group respectively (P < 0.05), the quantity of HBV-DNA decreased after treatment from 10(6.83 +/- 1.27) copy/ml to 10(3.35 +/- 3.08) copy/ml. Among them, in patient with HBeAg negative conversion, the pretreatment quantity of HBV-DNA was 10(6.30 +/- 1.42) copy/ml, while in those with no HBeAg negative conversion, it was 10(7.23 +/- 1.23) copy/ml, the difference was significant.
CONCLUSION:
Oxymatrine is effective in treating chronic hepatitis B. The therapeutic effect is better for patients with lower quantity of serum HBV-DNA.
AuthorsYan-xi Chen, Bai-yuan Mao, Jian-hua Jiang
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 22 Issue 5 Pg. 335-6 (May 2002) ISSN: 1003-5370 [Print] China
PMID12584828 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Alkaloids
  • Antiviral Agents
  • DNA, Viral
  • Hepatitis B e Antigens
  • Quinolizines
  • oxymatrine
Topics
  • Adult
  • Alkaloids (therapeutic use)
  • Antiviral Agents (therapeutic use)
  • DNA, Viral (blood)
  • Female
  • Hepatitis B e Antigens (blood)
  • Hepatitis B virus (genetics, isolation & purification)
  • Hepatitis B, Chronic (drug therapy, virology)
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Quinolizines

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