HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Nephrotic syndrome due to primary AL amyloidosis, successfully treated with VAD and subsequent high-dose melphalan followed by autologous peripheral blood stem cell transplantation.

Abstract
Primary AL amyloidosis involves vital organs from the early phase of illness, resulting in a poor prognosis. We report a patient with nephrotic syndrome due to this type of amyloidosis, who was successfully treated with two courses of VAD (vincristine, doxorubicin and dexamethasone) and subsequent high-dose melphalan (140 mg/m2) with autologous stem cell support. Following the serial chemotherapy his proteinuria improved, and M protein became undetectable in both serum and urine. To avoid the progression of primary AL amyloidosis, intensive chemotherapy should be actively used when the general status and vital organ functions are well preserved.
AuthorsTakahisa Gono, Masayuki Matsuda, Naoko Dohi, Kenichi Hoshi, Tsuyoshi Tada, Kazuo Sakashita, Kenichi Koike, Masatsugu Aizawa, Shu-ichi Ikeda
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 42 Issue 1 Pg. 72-7 (Jan 2003) ISSN: 0918-2918 [Print] Japan
PMID12583623 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Amyloid
  • Etoposide
  • Doxorubicin
  • Melphalan
Topics
  • Amyloid (metabolism)
  • Amyloidosis (complications, pathology, therapy)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Etoposide (administration & dosage)
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Melphalan (administration & dosage)
  • Middle Aged
  • Nephrotic Syndrome (etiology, pathology, therapy)
  • Transplantation, Autologous

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: