Proliferating cell nuclear antigen and Ki67 immunoreactivity in ameloblastomas.

Abstract

OBJECTIVE:

This study used proliferating cell nuclear antigen (PCNA) and Ki67 to evaluate and compare the in situ proliferative activity of (1) solid and multicystic and (2) unicystic ameloblastomas in an attempt to provide a scientific basis for any differences in biologic behavior that exists between these 2 groups of lesions.

STUDY DESIGN:

Twenty archival tissue sections, 10 of primary unicystic and 10 of solid and multicystic ameloblastomas, were immunohistochemically stained with PCNA and Ki67 antisera. Immunoreactivity was evaluated by the counting of cells, and the data obtained were statistically analyzed.

RESULTS:

The results showed that cellular proliferative activity varied within the ameloblastoma types. The unicystic ameloblastomas showed statistically significantly higher PCNA and Ki67 labeling indices than the solid and multicystic variant.

CONCLUSION:

There appears, therefore, to be no correlation between proliferative activity as shown by these proteins and reported biologic behavior.

• Authors: Shabnum Meer, Jacqueline S Galpin, Mario Altini, Hedley Coleman, Hasiena Ali
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 95 Issue 2 Pg. 213-21 (Feb 2003) ISSN: 1079-2104 [Print] United States
• PMID: 12582363 (Publication Type: Journal Article)

Chemical References

• Ki-67 Antigen
• Proliferating Cell Nuclear Antigen

Topics

• Ameloblastoma (chemistry, pathology)
• Analysis of Variance
• Cell Division
• Humans
• Immunohistochemistry
• Jaw Neoplasms (chemistry, pathology)
• Ki-67 Antigen (analysis)
• Observer Variation
• Proliferating Cell Nuclear Antigen (analysis)